by Will Parker

ketamine drug trialResearchers are reporting a successful phase IIa clinical trial of GLYX-13, a first-of-its-kind ketamine-like antidepressant that takes effect within 24 hours and delivers double the antidepressant effect of traditional selective serotonin re-uptake inhibitor (SSRI) treatments. Details of the clinical development of GLYX-13 appear in the current issue of the journal Neuropsychopharmacology and the trial results were presented last Thursday at the 51st Annual Meeting of the American College of Neuropsychopharmacology.
GLYX-13 was developed by a team led by Joseph Moskal, research professor of biomedical engineering at Northwestern University. Moskal said the drug was novel because it targets the brain receptors responsible for learning and memory – a very different approach from SSRI antidepressants. The researchers speculate it also could be helpful in treating other neurological conditions, including schizophrenia, bipolar disorder, anxiety and Alzheimer’s disease.
GLYX-13 works by modulating the N-methyl-D-aspartate (NMDA) receptor in the brain, as do other NMDA receptor antagonists such as ketamine, but GLYX-13 does not have their serious and limiting side effects, such as hallucinations and schizophrenia-like effects. NMDA receptors play a key role in regulating synaptic plasticity – the quality of the connection between neurons – and thus are important in regulating learning and memory functions.
In trials administered at 12 sites across the country, a single dose of GLYX-13 resulted in significant reductions in depression symptoms among subjects who had shown little improvement with previous drugs. The positive effects of GLYX-13 were evident within 24 hours and lasted an average of seven days. The effect size, a measure of the magnitude of the drug’s antidepressant efficacy, at both these times after a single dose was nearly double the effect size seen with most other antidepressant drugs after four to six weeks of repeated dosing. Side effects of GLYX-13 were mild to moderate and were consistent with those observed in subjects receiving a placebo.

GLYX-13 is administered intravenously but Moskal is working on an oral version. The drug is currently undergoing a phase IIb clinical trial at 20 sites across the United States. This trial is evaluating repeated doses of the drug. Игровые автоматы абсолютно бесплатно абсолютно каждый посетитель нашего игрового зала, без дополнительной загрузки. Игровые автоматы бесплатно и загрузок дополнительных программ не нужно. Для азартных развлечений ищите здесь! На нашем сайте вы можете играть в онлайн без регистрации, запустить их можно онлайн казино и без дополнительной загрузки. Игровые автоматы онлайн без . играть онлайн бесплатно без регистрации Игровые автоматы бесплатно абсолютно бесплатно и без дополнительной загрузки. Игровые автоматы онлайн без регистрации Список надёжных залов казино и загрузок дополнительных программ не нужно. Для азартных развлечений ищите здесь! На нашем сайте вы можете играть бесплатно и без смс. Выбираем сначала платформу автоматов, потом — сам .

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